关键词: 角膜接触镜, 药物缓释系统, 青光眼, 眼压

Abstract: Contact lenses (CL) could be loaded with more than one drug through various methods (such as soaking CL in drug solution,  adding vitamin E barrier,  applying polymeric colloidal nanoparticle,  etc.) to form an ocular sustained-release system,  which could reduce side effects and increase bioavailability of drugs. Different methods had their limitations and limited their clinical application and industrial production. Drug loaded by soaking method had obvious burst release,  and it was difficult to achieve an effective concentration of drugs for a long time. Methods of adding vitamin E barrier and loading drug in polymeric film within CL can prolong retention time of drugs, however,  they can change the physical properties of the CL at the same time. Polymeric colloidal nanoparticle drug delivery system could affect stability of drugs and waste a lot of drugs. Cyclodextrin and its derivatives that can be used for the sustained release of hydrophobic drugs can also affect the physical properties of the CL. The molecular imprinting method and supercritical fluid technology were relatively complicated,  and there were many factors influence their functional time of drug,  which made it was difficult to achieve industrialization. (Int Rev Ophthalmol,  2020,  44:  402-407)

Key words: contact lenses, drug delivery system, glaucoma, intraocular pressure